The Effect of Vitamin C-Loaded Electrospun Polycaprolactone/Poly (Glycerol Sebacate) Fibers for Peripheral Nerve Tissue Engineering

Vitamin C (VC) is an essential supplement that plays a vital role in cellular processes and functions has been applied for therapeutic purposes many years. The beneficial effects of VC on peripheral nerve regeneration have gained lots attention. In this study, electrospun polycaprolactone (PCL)/polyglycerol sebacate (PGS) fibers incorporated with different concentrations (5, 10, 15 wt.%) were developed tissue engineering. morphology the was investigated using scanning electron microscope (SEM), Fourier-transform infrared spectroscopy (FTIR), tensile analysis (Young’s modulus, ultimate strength (UTS), elongation at break), release profile from PCL/PGS fibers, vitro degradation, water uptake behavior, contact angle measurements also studied. MTT assay SEM utilized to evaluate attachment viability pheochromocytoma cells (PC12) scaffolds. results showed all scaffolds had uniform diameter mean deceased 1.24 0.88 µm followed by increasing VC. Young’s modulus UTS enhanced percentage. demonstrated containing 5 wt.% greater rate among other Our outcome indicated possible applicability